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Farsala said:

Hard to say.

But one memory I had in Skyrim was trying to kill the children because they annoyed me. They were invincible though. I think it would have been cool if you could but then the game soft locks you into a world where your character is a child murderer and is hunted down at every opportunity.

Fallout 1/2 - you get "Childkiller" trait after you start killing children, so, IIRC, your reputation falls drastically, bounty hunters are going after you and most NPCs dislike you (which makes quests and trading harder).

Not many devs have the balls to include that in their games anymore.

OT: wiping out whole planets in Star Trek: Birth of Federation in one of playthroughs (as Cardassian, if my memory serves me), some 20-25 years ago.