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It's difficult to argue against 2600, NES and Playstation 1. They were each a major stepping stones, creating industry standards. The GameBoy is of course also up there, as the most influential handheld. N64 deserves to be mentioned for the analogue stick (though the Saturn might have introduced it first technically??) and especially for some of it's games that definitely were templates for generations of games (Super Mario 64, The Legend of Zelda: Ocarina of Time, Mario Kart 64, Smash Bros., 007 GoldenEye).