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My top three would be Super Mario Bros., The Legend of Zelda, and Halo: Combat Evolved. Each one satisfies the following criteria:

  • Great game
  • Launched a huge, successful franchise that continues to this day (although Halo post-2010 is more than a little shaky)
  • Helped change the rules and expectations of the genre
  • Helped secure a console maker's place in the game industry

If we're just identifying the highest quality game that started a series, then I vote Deus Ex.