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Another great one is the Shrink Ray from Duke Nukem 3D, here at 4:12


Tons of fun in multiplayer. With a direct hit you get shrunk for 30 seconds or so and have to avoid the person that shrunk you trying to stomp on you. Your perspective changes to that of a mouse and you see this giant foot coming at you while the other player frantically tries to squish a mouse running around.


Ratchet and Clank carried the torch for inventive cool weapons later on, lot of fun ones. 
https://www.gamespot.com/gallery/ratchet-clank-best-weapons-of-all-time/2900-4437/#9
Fully agree with the list
The Zurkon family, Groovitron, RYNO, Sheepinator, Pixelizer, Suck Cannon are all great.


In Unreal Tournament my favorite was the Flak Cannon, so satisfying to use