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I'm not certain that anthropogenic climate change is real but I think its far more likely than not. Basically if the current climate models turn out to be anywhere near correct then humanity is going to be forced to change; we literally cannot keep polluting as we are.
It's going to be a bumpy ride for the next century thats for sure.

If anthropogenic climate change is real (as I think it most likely is) I can see it as a possible candidate for the cause of the next extinction event.