As far as games I think have a high chance to be nominated would be
Astro Bot
FF7 Rebirth
Metaphor: ReFantazio
Helldivers 2
Like A Dragon: Infinite Wealth
There are several titles that I think could be wild cards
Dragon Age: The Veilguard
Silent Hill 2
I think they're highly unlikely, but each games most recent trailers have shown a lot of promise. I would say S.T.A.L.K.E.R. 2 could have a chance, but, the release date is past TGA's cutoff date how you gonna have an awards ceremony for a specific year and not take into consideration every single game that released that year?!
Unicorn Overlord and Kunitsu-Gami: Path of the Goddess have been my favorite games of the year so far though. But I hope Astro Bot wins if it turns out to be as good as we're all hoping it is.