I personally voted for Gears of War: E-Day. What an awesome surprise! As a huge fan of the original trilogy, I never thought we would actually see the start of the war with the Locust along with the beginning of the deep friendship between Marcus Fenix and Dom Santiago that we all know and love. Seeing Dom again.......was such a heartwarming moment. Right when the Mad World piano settled in too. Nostalgia hit hard!
And with The Coalition going to the series roots of a linear campaign, the sense of horror (especially now since the Locust are this new terrifying force, which you could see from the reveal trailer Marcus struggled fighting a drone) with the Locust being described as "living nightmares" and seeing what will be the fall of human civilization is probably going to the darkest and grittiest story yet in the Gears of War series. Can't wait!
Doom: The Dark Ages, Clair Obscur: Expedition 33, S.T.A.L.K.E.R 2, Fable, Indiana Jones, Perfect Dark, and Avowed being the other major notable highlights. Probably in that order.