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It depends. Best game, as in, you know, the most innovative, creative, polished etc... that would probably go to Super Metroid. No game on the SNES that I can think of has been more copied than that one (if you can think of something, let me know). If you're talking cultural impact, then noting beats DKC 1. Before that game, Sega was eating their lunch. After, it was all anyone could talk about, and it singlehandedly pulled the SNES into the lead in the US. No game released during that gen was as impactful on sales as that one.