I'm still going with Journey since it was such a unique experience and the only game I've replayed more than 20 times.
From the cut down selection of 2011 LA Noire stands out now (with Portal 2, Dark Souls and Skyrim absent). However Portal 2 would take it from Journey for me for the added humor. Deus Ex and Uncharted 3 can trade places with LA Noire any time though. All 3 have their highs and lows.
My top 50 order for 2011-2012
Portal 2
Dark Souls
Journey
Skyrim
Fez