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I think Super Mario Bros. 3 is the answer, however it would not exist without Super Mario Bros.

Pac-Man is hard to beat as well! Too bad it did not make the move to side scroller well. It could have been exactly like Mario (collect the dots instead of coins, the big dots give you power ups).

Personally, I was much more into adventure games, so titles like Metroid, Zelda and Phantasy Star were much more impactful.