I grew up in 80s with Spiderman comics, but I'm yet to play a Spiderman game that I really liked.
I never cared for Batman comics, but I often played Batman games that I really liked (Batman Arkham Asylum probably being favourite).
Just for the sake of nostalgia, I'll throw in Samurai Warrior: Battles of Usagi Yojimbo from C64 as well.