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GB to GBA and GBA to DS were probably the best for Nintendo. Even though the GBA sold less than the GB, that is because Nintendo cut the GBA's life very short and because the GB had an incredibly long life. Had Nintendo waited at least 2 years to release the DS, the GBA probably would've been a 100 million seller, marking the only time (so far) that Nintendo would've had back to back 100 million sellers (a feat that has only been accomplished once, with the transition from PS1 to PS2). I hesitate to say NES to SNES because even though Nintendo was the market leader in both cases, their reign was threatened by SEGA and frankly, SEGA almost beat them.