Some of mine have been mentioned already, so I'll go with Metroid Samus Returns for the 3DS. While it didn't sell great, it marked the start of what has become a renaissance for 3d Metroid after over a decade of nothing and reinvigorated the franchise which had been dormant for 7 years since Other M. It looks great in 3D and proved the 3DS wasn't dead yet even though the Switch had already launched.