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All Martial Arts fighting styles are designed to kill and incapacitate - that's the point of fighting. Although you can theoretically try to strike to the eyes, it's very difficult to hit and very unlikely to knock someone out compared to the chin, nose, or side of the head.

The reason why it is "illegal" in MMA is that... well... real fights are over pretty fast so it's not entirely genuine. When people make contact (even accidental light taps) the person getting hit usually goes down immediately. That's why boxers wear huge pads on their hands.