Okay I'm gonna give this thread a go. Hopefully my hints aren't too easy.
#50 This First Person Shooter which involves some platforming was somewhat overshadowed when it first released.
#49 This is the third game from this franchise which is known mainly for it's difficulty
#48 This is the third game in this Franchise which hadn't seen a new entry for many years.
#47 A 3d platformer in which you collect "Time Pieces".
#46 The first 3d entry from this well known franchise.
#45 A Jrpg from the developer also known for Dark Cloud.