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Machina said:

OK, some more clues:

#50 - Brothers on a small screen make for a sales juggernaut.

#46 - This 1980s classic was recently remastered/remade, although not to much fanfare. The remake was official but developed basically by a team of fan developers who named their company after a core part of the game.

#45 - The name of this game suggests there aren't many people left alive, although you certainly encounter a lot of them.

50: Has to be a Mario game, but on a small screen, so a handheld. Mario Land doesn’t have the word Bros in it, and the biggest sales juggernaut among them is New Super Mario Bros on DS, so NSMB?

46: I feel like I can know this, let me think some more, unless someone else knows it instead.

45: The Last of Us.