Whatever you are used to using at the time. I used to think XBox controllers were uncomfortable, because I primarily gamed on PS consoles. Also when I was playing WiiU, the gamepad never felt as bulky as it did when I first tried it.
After using Switch as my main device since launch, PS controllers started to feel wierd when I used them for the odd game that I had to play that wasn't on Switch. Anything other than a pro controller felt wierd.
Now I have a Series X, and after playing it mainly since launch the XBox controller feels most comfortable to me. My pro controller feels a bit odd now, despite having a similar layout (let alone my PS4). So as long as the controller itself isn't complete shit, like say the N64, it should always feel the most natural if that is what you are mainly using. Your personal ability to adapt is more important than the controller itself IMO.
Unless we are talking about DPads in particular for games that use them heavily, like fighting games. In that case I usually give the edge to PS controllers (though they may my thumbs blister after a time). It is worth noting that I have not tried the new pad on the Series controller in a fighting game yet, so that one is still up in the air.
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