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It's mainly the same as small dogs.

The problem is two fold. First, if you are intimidated, that's something the dog will pick up on. So, that could be part of why a big dog may respond weirdly to you. Also, respect a dog's body language. Dogs will generally let you know if they're feeling uncomfortable. If a dog's ears are pinned back, if their tail is between their legs or wagging very slowly, or if their eyes narrow, and of course if they growl, they are telling you they're scared or stressed and you need to back off.

Also, big dogs don't know they're big. My mom's little pappillon, when he was younger, would frequently jump at me. My cousin's German Shepard also did that sometimes, but obviously that's kind of a problem.