I also have troubles with big monitors and, when I upgraded from my 23" one to the 25" I'm using now, I thought I would have troubles getting used to the new size, but I can say that the transition was very smooth and didn't had any problems at all.
Please excuse my bad English.
Currently gaming on a PC with an i5-4670k@stock (for now), 16Gb RAM 1600 MHz and a GTX 1070
Steam / Live / NNID : jonxiquet Add me if you want, but I'm a single player gamer.