Honestly, seeing as its your first time with the game I think you should play straighforward as possible until you familiarize with the more elaborate mechanics, by which I mean go the physical route and dont bother much with alchemy and/or glyphs, except maybe Quen and Igni. Do try to learn quickly how mutations works cause that will boost a lot of your combat prowess.
I guess you could look up where to find witcher gear of certain schools. Its the best and easiest way to equip yourself with good items and having that gear makes using the ones that enemies drop - which are rather weak - irrelevant. Of course you might wanna try them for cosmetic reasons, seeing its your first time playing.
Other than that, save frequently and dont try to romance both Triss and Yen. As you progress the other elements of the game might become more important but I assume you'd already be a bit familiar with how they work.
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