One of the only true "game breaking glitches" I've ever encountered: Mine was in Tomb Raider 2013. There's a part where you had to pull a box off of a raised location using a new tool Lara Croft discovers. The box is supposed to smash the floor allowing Lara to proceed.
The box did not smash the floor. It went right through it.
At that point, the game was broken until they could patch it. Crazy thing was that I got the game AGAIN for PS4 and the exact same glitch happened.
This post really makes me want to replay Tomb Raider 2013, though...
*at this point, I've just realized that I read the word "Cliches" as "Glitches". I'll leave now. 😢