Well it's definitely possible for the human race to die out as long as we're all on a single planet. Lots of theoretically possible scenarios like meteors hitting, huge-ass volcanos erupting, and nuclear war breaking out, although none of them is all that likely. We'll probably be off this rock by the time the Sun goes out, although then there's the possibility of catastrophies on a galactic scale messing the whole neighbourhood, hostile non-human civilizations etc.
If you're waiting for some kind of a supernatural apocalypse on some manner of magical date, then I'm afraid you're going to be dissappointed. Groups of wackos have been predicting the end of the world/armageddon/rapture/whatever to occur during their lifetime for at least as long as there's been civilization, and I'm sure you can guess if any of them has ever been right or not.







