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Gazz said:
XP 64 bit has never taken off, with all the driver issues and hardly anyone optimising for Vista 64 bit Id say your safest bet is to use 32.

 

While I agree that XP64 was almost completely ignored by hardware vendors, MS requires vendors that get their vista drivers WHQL'd to provide 32 and 64 bit drivers. No guarentee you'll be able to get drivers for smaller vendors (ahem...Line 6, though they've just released drivers) or older hardware, but there are significantly more available for Vista 64 than there ever was for XP64.