Reasonable on 23 June 2008
Gotta be Deus Ex - they took one of the most critically lauded games ever and managed to practically kill it with one of the most poorly judged attempts to mix a PC game with an Xbox release for the sequel.
Heck I almost never got into consoles at all I was so pissed with how the 'Box seemed responsible for ruining a sequel I was looking forward to more than any before or since.
That takes some serious effort beyond the usual killing of a franchise by milking it to death IMHO.
Try to be reasonable... its easier than you think...
