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Ok, here are my first few clues:

50. This GBA beatem up is based on a classic Japanese cartoon.
49.  When this Genesis game was released the franchise was associated with Nintendo consoles.
48.  This trackball arcade game was the first successful arcade game to have a female developer (or co-developer in this case).
47.  This Wii U game was not developed by Nintendo, but it uses Nintendo IP and makes good use of the Wii U gamepad.
46.  This GBA tactical game has a plot similar to the Neverending Story, which is ironic, since the franchise name that this game comes from means the exact opposite.