MCU works because they're all based in the same universe to begin with, Nathan Drake meeting alloy/kratos makes no sense at all, and having portals that take them to each others realities of whatever is just cheesy.
So no it wouldn't work. Existing IPs already based in universes that could conceivably be the same would work.
Well the new God of War is norse so there's the realms and Nathan Drake's world which he ransancked of its treasures. Now he can go treasure hunting in some other world with Aloy. :)
If someone asks why I'm using an alt account, CGI and Truckusaurus got me a temp approval until I get my iconic and notorious "kurasakiichimaru" account back. :p