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Prime 4 100% will, the hype for the game already eclipses any hype  all other Metroid games combined ever got pre-release and all they've shown us is the title card. It will also be on a hugely successful platform, so that pretty much locks it to set the franchise sales record. Animal Crossing stands a good shot if it's as well received as New Leaf was and is released during the holiday. Pokemon is probably next to no chance. 32m is an absurd number to beat, especially when the last 5 gens have all consistently sold between 15-18m. That range seems to be pretty set in stone for the franchise.