Injuries take longer to recover from. Dumb things you did / bad habits you had in your youth come back to haunt you. You tend to have a lot of old shit, some have become rare collectors items, most of it obsolete trash. Media in general doesn't surprise you much any longer.
It isn't all bad though. Your family has probably expanded by then, you've had opportunities to travel and explore a bit, you're more likely to discern good investments from bad (well, as far as gaming goes), and you're probably in a better financial situation to enjoy the latest tech. Best of all, you've got more XP to know how to handle all manner of social situations.