From the games i've played, it would have to be a toss-up between Breath of the Wild and Xenoblade Chronicles. It is obvious however from everyone else's choices that there are many fine single-player games i have yet to play!
NNID: b00moscone
Switch ID: SW-5475-6755-1986
3DS friend-Code: 4613-6380-5406
PSN: b00mosconi