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I wouldn't hit anyone no matter their size and gender unless I feel seriously threatened by them.
Likewise, if I felt my life was threatened, or that person is about to inflict serious bodily harm on me, I'd hit just about anyone.

If you are stronger than the other person and use that strength to violate them just because you're angry they made a snide comment, or else did something that doesn't really harm you, you're in the wrong.
If you are being abused by a person who is body-wise weaker than you, use your strength to stop them, get out of the situation and report them.
If someone who is weaker than you seriously threatenes your life or well being, fight them with all you have.