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It will not be Wii Fit, alas.

SSBB, Spore, MGS4 all stand a chance, as does whatever Nintendo unveils for this year

GTAIV stands a small chance, but I don't think it can win, being in the same year as MGSIV
Similarly, SSBB will ruin Mario Kart's chances

I doubt Starcraft II will get it.

LBP planet is awesome, but not GOTY material