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d21lewis said:

Could it happen again? What scenario could lead to such an extreme course of events?

Doubt a 3rd world war would happend.

But if sh*t got crazy enough, I could see Islam as a religion being banned (everywhere) , and every muslim country in the world iradicated.

It would take a new "hitler" like character to raise up, and gather the west & eastern world, to agree on it.

 

as to what scenario... maybe some terrorist that got hold a nuke and set it off in a highly populated US city.