1) Wiimote
The sensor bar was far too unreliable. You had to manually replace the batteries after the charge ran out. The controller is made to hold like a remote, and while this works well for rail shooters (Sin and Punishment is fantastic), it is otherwise extremely awkward to use.
2) Colecovision
You had to hold your hand as if you are picking up a disc off of a table to move the joystick.
3) Xbox
Far too large. The button and analog layout is scrambled. It didn't even possess a passable D-pad making fighting games almost unplayable. The S version was slightly better.