Why From Software? I would not want a Metroid game to play like a Souls game. And I really don't even see the correlation, as Metroid plays nothing like a melee weapon based Souls game.
I've stated it many times in the past, but while I'd be OK with another Prime game by Retro. But the Metroid game I truly want, is a fully 2D, sprite based/hand drawn Metroid in the vein of Super Metroid, either by Nintendo themselves if they'd ever get off their ass (they did great with Zero Mission, after all), or a developer that specializes in 2D games, like Way Forward, Vanillaware, or Good-Feel, etc.
I've been waiting for a TRUE Super Metroid sequel forever, and while Fusion was a solid game, it really wasn't a Super Metroid type game (too linear, forced story elements).