Final Fantasy 12 & 13 - Put about eight hours into each, just couldn't stay interested.
Resident Evil (post 3) - Code Veronica had Claire doing slow-mo action movie BS and nothing else of particular interest. RE4 gameplay was okay, but the tone was completely wrong for the series. The remake of #1 was good, and 7 sounds like it might be, but Capcom almost completely killed my interest in the franchise.
Breath of Fire 5 - It's a neat concept, and it plays alright, but I just haven't been able to do one solid playthrough of it yet. I just get bored and move on.
Assassin's Creed (series) - Just can't do it. I liked Shadow of Mordor, so maybe its just a setting thing?
Legend of Zelda (post Majora's Mask) - Not sure what happened, but one of my favorite childhood series became a chore to play. The portable titles seemed weak after Links Awakening, and the home titles kept getting more bloated interest-killing tutorial intros. Never got real far in KH2 for about the same reason.
Pokemon is another I was never able to get very far into, even back when it was Blue/Red. I like the concept, and enjoyed my rental of Pokemon Snap, but that's as far as its ever gone.
