RE 4, hands down.Its not even a contest really.
While TLOU is an excellent game, RE 4 is a masterpiece that revolutionized gaming(3rd person games in particular) and influenced games going foward.
My (locked) thread about how difficulty should be a decision for the developers, not the gamers.
https://gamrconnect.vgchartz.com/thread.php?id=241866&page=1