If it will be perceived as a portable that can be plugged on a TV too, it will need a price cut very soon, but once Ninty will have fixed that, it will as soon kill 3DS and it will end up selling roughly the same lifetime, or maybe a little more.
If it will be perceived as a home console that you can carry around too, I really can't predict anything, it could succeed, fail or anything inbetween.
Financially, if Ninty didn't fall for a horribly one-sided deal with NVidia as MS did for the first XB, it will only need decent sales to break even and then bring some profits too, even twice as many sales as Wii U should do, as pay online will help (although it could harm sales numbers a little).