The difference is noticeable once you zoom into 100% or are displaying this on a 4k monitor. The upscaling effort is pretty good though. Nothing can really beat native but they are trying their hardest. Imo, this picture doesn't do the difference justice cause there isn't much to look at. Once we see the environments and effects and etc, that is where the difference in settings/res will come into play.
Anime: Haruhi Nsfw Anime Thread