naznatips on 27 June 2007
It already exists, it just uses anime characters instead of Nintendo characters. It's called Jump Ultimate Stars, and it's one of the best DS games ever made. http://youtube.com/watch?v=tlaJw_TUoTc
So, I guess in answer to your question: yes, it can be done, it already has been done (and very capably). There is no touch control, but there is online multiplayer, and it's easy to play even without speaking Japanese (there is a full guide on gamefaqs).
