Borderlands makes you search through Skag crap quite often. I mean, no thanks, I don't really want whatever I find in there.
One thing that was really actually hard was in This War of Mine, if you go to one place, there is a soldier talking up this girl. You can listen through the door. If you let it play out, he takes her out back and forces her to have sex. If you come across this early in the game, and you try to interfere, he'll kill the character you're playing because he's well armed. That can totally screw up your play-through and can even lead to your other characters giving up hope.
First time, I tried to help and lost one my characters. Second time ... I had to let it happen. I had no choice but it still left a bad taste in my mouth. Of course, my other characters didn't like that, either.
