Daaaang, now that is a hard one to determine. There are quite a number of great titles to consider. Super Mario Bros, Donkey Kong, The Legend of Zelda, Mario 64, Pikmin, Mario Galaxy, etc. A case could be made for any of them being his best works. The man has done quite a lot of during his time. It's like how Iwata once said "Anything Miyamoto touched turned to gold". or something like that....
If I had to give it to one though, probably Mario Galaxy. Mario 64 set the ground work, and I love that game as well, but it seems to be that Galaxy was when the 3D platforming genre was perfected. I've heard people say 1 and 2 are great, and is considered one of the best games in the 7th gen, or even one of the best ever.
So yeah, gotta give it to the refined game.
Dance my pretties!
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