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TheLegendofDS said:

And Other M is canon and the Prime Series isn't because Sakamoto said so and he also said that Samus isn't a newhalf and again this comes from the Metroid Wiki:" series co-creator Yoshio Sakamoto, who joked in 2004 that a Metroid game on the PlayStation 2 would be "as likely as Samus Aran being a newhalf."

 

The thing is, the Metroid Wiki doesn't take anything for granted:

During a post-development interview following Super Metroid 's release in 1994, when asked if there were any secrets about Samus that only he knew, Matsuoka claimed that Samus was actually a transgender woman. A later interview with Yoshio Sakamoto would later joke about the same quote from said interview, saying that a Metroid game was as likely to come to PS2 as Samus was to be a transvestite. This has recently led to much debate regarding the legitimacy of the claim [...]


Two developers, one says one thing, the other, a different one. Hence, the possibility still lies there.