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I would do something like the book Foundation describes, save the world's culture, languages, science, etc. in one place in case of disaster (including self destruction or massive environmental destruction). Massive bunkers, that would be challenging to get full autonomy for hundreds of years, perhaps underground farms, stockpile of petrol, components, why not a zoo, call me Noah, etc. and we'd spend time composing poems, listening to music, reading books, lazily waiting ah ah
Not that serious, but I can't really imagine "changing" the world in a meaningful way. I mean if we go in the right direction, Africa will develop, diseases will be cured, but if we go in the wrong direction, and I think we are... here I am for the second round ! A second chance for humanity, that would change the world... perhaps.