I think that the game will be accessible gameplay wise but seriously if you haven't played the other games you won't understand the story... And it's a big mess, I once spent more than 2 hours discussing with a firend of mine why 3 is needed to understand 2 and seriously i reccomend probably to see at the gametrailers metal gear retrospective they are making... number 1 helped explain the basic of the NES games... and i imagine you can get basic knoweldge to be prepared for 4...







