Nintendo not going along with the CD drive.. that really changed a lot of things. Besides that, it's hard to really point out any others. Virtual Boy was a flop, but it was more of an experiment I believe. Obviously the biggest mistake was how Atari and the gaming industry in general handled things in the past, causing that big crash before Nintendo helped pick it back up.
And I do think Sega handled things poorly, or they would maybe still be around.







