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sc94597 said:

Considering the type of game The Binding of Isaac is, I would think it is more descriptive of him as a developer than the capabilities of either platform. Maybe his issue has much more to do with the architecture and hardware design of the platforms than maxing out these platforms? 

I don't see exactly why we should accuse bad talent unless anyone else can prove him otherwise ...

There ARE demanding games with 2D sprites. Just because it takes less resources to render a 2D game than a 3D game doesn't that the requirements to render a 2D game are next to zero ...