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Depends on what you prefer, for me Witcher 3 and Fallout 4 are not really comparable, apart from 'open-world' and 'RPG' labels.

If you're looking for a solid story and memorable characters set in open world with stronger RPG focus, pick W3.
If you're looking for open-world with some story and FPS with RPG elements (calling FO4 an RPG is really a stretch) pick FO4.

I prefer Witcher 3 to FO4, but then again I have strong feelings about what Bethesda did with Fallout IP in FO3 and especially in FO4.