Both, using separate slots, with the auto-save being useful for when I forget to save manually. Basically, I want full control of my saves, but having a safety backup is appreciated.
Just don't make me fight the system, please. I had to shut off auto-save in GTA5, and the game kept complaining that it couldn't save. TLoU had me making two manual saves every so often just to bypass the "constant auto-saving in the most recent save slot" BS.







