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I use cut out pieces of cardboard from old boxes (to match the cart slot width), douse it in 99% rubbing alcohol (so it evaporates cleanly), and slide the cardboard into and out of the cart slot several times.

Give if 5 minutes to totally evaporate, and test. I've cleaned MANY an old retro system using this method, and you don't have to buy any special kit, just old boxes and rubbing alcohol. Of course q-tip + alcohol clean the games as well.

Beyond that, the next thing that tends to go awry is old capacitors.

Now my advice is that if your cleaning attempts fail, just get another Genesis, they're still quite cheap for now. MK1 'High Definition' models make great Gennys (in general, superior AV performance in my experience, though there is a big guide out there on the subject).