I remembered earlier how Nolan North (plays David) let slip there will be a new TLoU. And also how Troy Baker (plays Joel) knows nothing.
This could suggest that there's no Joel in the next game... but that's just a possibility still at this stage.
Anyway, what would you like the next instalment to be about?
Focus on a character from TloU, show how they got to where they are (e.g. David, Joel's brother, Tess etc)
Have chapters on a few different characters with their own separate stories
The early years of Joel (and Ellie), how he survived the fall and got to where he did.
A direct following sequel to TLoU, I think the first game does leave this possibility.
Completely New characters, set in a different part of the states, or world even.
Or something else! I know a user on here wants an open world online game set in the universe.